Role of signal transduction pathways in lung inflammatory responses

A variety of cell types participate in lung inflammation. Macrophages and epithelial cells play an important role in the inflammatory process by releasing cytokines in a complex cell to cell network. Interleukins are important mediators of this cell signalling. The interleukins IL-6 and IL-8 are released from epithelial cells in response to noxious agents such as particles, bacterial and fungal toxins and various chemicals. Though the involvement of, e.g. NF-IL-6 (C/EBP-beta) in the regulation of interleukins has been reported, the role of different signal transduction pathways in the regulation of these mediators has not been thoroughly investigated in lung epithelial cells. The involvement of different signal transduction pathways in the release of inflammatory markers is discussed with special emphasis on the effect of lung toxic compounds in human and rat lung epithelial cells.