Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression profiling in toxicology--potentials and limitations.

S Steiner1, N L Anderson

  • 1Large Scale Biology Corporation, 9620 Medical Center Drive, Rockville, MD, USA. steiner@lsbc.com

Toxicology Letters
|March 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diel rhythm of volatile emissions of males and females of the peach fruit fly Bactrocera zonata.

Journal of insect physiology·2019
Same author

[Sleep Apnea and Mechanical Ventilation - Impact on Clinical Course and Perioperative Management].

Pneumologie (Stuttgart, Germany)·2017
Same author

Interferon-free regimens improve portal hypertension and histological necroinflammation in HIV/HCV patients with advanced liver disease.

Alimentary pharmacology & therapeutics·2016
Same author

Mechanism and Kinetics of Acetyl-Lysine Binding to Bromodomains.

Journal of chemical theory and computation·2015
Same author

Cardiac findings in obesity hypoventilation syndrome: is there a need for specific approach and evaluation?

Internal medicine journal·2015
Same author

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.

Nature·2015
Same journal

hERG Channel Blockade and Additive Interactions of Magnolol and Honokiol from Magnolia Species.

Toxicology letters·2026
Same journal

Evaluation of dose-dependent hematotoxic effects of celastrol on human blood cells in vitro.

Toxicology letters·2026
Same journal

Environmental pharmaceutical and antibiotic mixtures: An exposomics-guided framework for mechanistic toxicology.

Toxicology letters·2026
Same journal

Size- and morphology-dependent cytotoxicity of metal-organic frameworks: Deciphering the structure-toxicity relationship.

Toxicology letters·2026
Same journal

Steroidogenesis suppression in H295R cells by 1,3-disubstituted ureas: A potential off-target effect of some sEH inhibitors.

Toxicology letters·2026
Same journal

Signaling pathways in tobacco smoking-induced cervical carcinogenesis: Beyond HPV-mediated activation.

Toxicology letters·2026
See all related articles

Genomics and proteomics advance drug development by revealing molecular fingerprints for efficacy and toxicity. This enables better drug selection and safety monitoring in clinical trials.

Area of Science:

  • Biotechnology
  • Pharmacology
  • Toxicology

Background:

  • Genomics and proteomics advancements offer new tools for pharmaceutical research.
  • Cells and organisms exhibit specific responses to drug treatments, creating molecular fingerprints.
  • These fingerprints can indicate a drug's effectiveness and potential harm.

Purpose of the Study:

  • To explore the impact of genomics and proteomics on pharmaceutical drug development.
  • To integrate gene expression profiling into toxicology for better drug assessment.
  • To gain insights into drug mechanisms, efficacy, and toxicity.

Main Methods:

  • Utilizing genomics and proteomics technologies.
  • Applying assays to profile treatment-related changes in gene expression.

Related Experiment Videos

  • Integrating these assays into state-of-the-art toxicology.

    • Main Results:

    • Identification of unique molecular fingerprints indicative of drug efficacy.
    • Detection of patterns associated with drug toxicity.
    • Gaining deeper understanding of drug action mechanisms.

    Conclusions:

    • Genomics and proteomics significantly enhance pharmaceutical drug development.
    • Profiling gene expression improves lead selection and monitoring of drug efficacy and safety.
    • Biologically relevant tissue and surrogate markers are key for pre-clinical and clinical studies.