Selective activity of Streblus asper on Mutans streptococci

Area of Science:

• Oral microbiology
• Natural product chemistry
• Dental hygiene

Background:

• Streptococcus mutans (S. mutans) is a primary pathogen in dental caries.
• Natural plant extracts are being explored for antimicrobial properties in oral care.
• Streblus asper leaf extract is a potential candidate for oral hygiene applications.

Purpose of the Study:

• To evaluate the antimicrobial effectiveness of a Streblus asper leaf extract mouthrinse.
• To assess the impact of the mouthrinse on S. mutans and total salivary bacteria.
• To determine changes in salivary pH and buffer capacity after mouthrinse use.

Main Methods:

• In vivo, single-blind, time-series study with 30 human subjects.
• Saliva samples collected pre-rinse and at multiple time points post-rinse (0-6 hours).
• Subjects rinsed with Streblus asper extract or distilled water (control) for 60 seconds.

Main Results:

• Streblus asper mouthrinse significantly reduced S. mutans counts compared to the control.
• No significant difference was observed in total salivary bacterial counts between the groups.
• The mouthrinse did not affect salivary pH or buffer capacity.

Conclusions:

• Streblus asper leaf extract mouthrinse demonstrates targeted antimicrobial activity against S. mutans.
• The mouthrinse appears to maintain oral ecological balance by not affecting total bacterial counts or salivary parameters.
• Streblus asper extract shows promise as a natural ingredient for reducing cariogenic bacteria without disrupting oral homeostasis.