Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gap junctional intercellular communication and carcinogenesis.

S Sulkowski, M Sulkowska, E Skrzydlewska

    Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
    |March 18, 2000
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cannabidiol protects keratinocyte cell membranes following exposure to UVB and hydrogen peroxide.

    Redox biology·2020
    Same author

    Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma from Patients with Neuroborreliosis.

    Lipids·2016
    Same author

    Professor Witold Nowicki - a greatly spirited pathologist.

    Polish journal of pathology : official journal of the Polish Society of Pathologists·2016
    Same author

    Acardius acephalus fetus--report of distinctive anatomical anomalies with regards to pathophysiology of TRAP sequence.

    Clinical and experimental obstetrics & gynecology·2016
    Same author

    Coexistence of mature cystic teratoma and adenocarcinoma in situ within atypical proliferative mucinous tumour of ovary--a case report of 35-year-old woman.

    European journal of gynaecological oncology·2015
    Same author

    The redox status of human breast cancer cell lines (MCF-7 and MDA-MB231) treated with novel dinuclear berenil-platinum(II) complexes.

    Die Pharmazie·2015

    Gap junctional intercellular communication allows direct cell-to-cell signaling, crucial for organismal homeostasis. This review explores how these connections influence non-genotoxic tumorigenesis.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Cancer Research

    Background:

    • Intercellular communication is vital for maintaining multicellular organism homeostasis.
    • Gap junctions represent a primary direct cell-to-cell signaling pathway.
    • Recent research highlights the role of gap junctions in experimental and human tumorigenesis.

    Discussion:

    • This review focuses on the mechanisms linking gap junctional communication to non-genotoxic tumorigenesis.
    • Understanding these pathways is key to deciphering cancer development independent of genetic mutations.
    • The direct exchange of signals via gap junctions can influence cellular proliferation and survival.

    Key Insights:

    • Gap junctional intercellular communication plays a significant role in non-genotoxic carcinogenesis.

    Related Experiment Videos

  • Specific molecular mechanisms mediate the influence of gap junctions on tumor development.
  • Dysregulation of gap junction function can promote tumorigenesis through non-mutagenic pathways.

    • Outlook:

    • Further research into gap junction modulation may offer novel therapeutic strategies for cancer.
    • Investigating the interplay between gap junctions and other cellular pathways is crucial.
    • Elucidating these mechanisms can provide insights into preventing and treating cancers not driven by genetic alterations.