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Fibrinogen and homocysteine levels in coronary artery disease

S Gheye1, A V Lakshmi, T P Krishna

  • 1National Institute of Nutrition, Hyderabad.

Indian Heart Journal
|March 18, 2000
PubMed

Insights

In the Indian population, elevated plasma fibrinogen and abdominal obesity are significantly linked to coronary artery disease. These factors, along with high cholesterol, contribute to the disease beyond traditional risks.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Traditional coronary artery disease (CAD) risk factors inadequately explain disease burden in India.
  • Emerging risk factors, including plasma fibrinogen and homocysteine, are recognized for their role in CAD.
  • Investigating novel risk factors is crucial for understanding CAD in diverse populations.

Purpose of the Study:

  • To assess the association of plasma fibrinogen, homocysteine, lipid profiles, and anthropometric parameters with angiographically confirmed CAD.
  • To explore relationships between biochemical and anthropometric markers in CAD patients.
  • To identify specific risk factors prevalent in the Indian population.

Main Methods:

  • A case-control study involving 58 male CAD patients (35-60 years) and 58 matched controls.
  • Measurement of plasma fibrinogen, homocysteine, lipid profiles, and anthropometric indices (waist-to-hip ratio, waist-to-thigh ratio).
  • Statistical comparison of parameters between CAD cases and control groups.

Main Results:

  • CAD cases exhibited significantly higher waist-to-hip ratio, waist-to-thigh ratio, plasma fibrinogen, and total cholesterol.
  • No significant difference in mean plasma total homocysteine levels was observed between cases and controls.
  • Elevated plasma fibrinogen and abdominal obesity demonstrated a significant association with CAD.

Conclusions:

  • Plasma fibrinogen and abdominal obesity are significant risk factors for coronary artery disease in the Indian population.
  • These factors contribute to CAD independently of conventional risk factors.
  • Further research into these markers can inform targeted prevention strategies for CAD in India.

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