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Identification and analysis of a third mouse Polycomb gene, MPc3
C S Hemenway1, B W Halligan, G C Gould
1Department of Pediatrics, and the Tulane Cancer Center, University School of Medicine, New Orleans, LA 70112, USA. chemenw@tmcpop.tmc.tulane.edu
Abstract:
A new mouse Polycomb (Pc) gene, MPc3, has been identified. The MPc3 protein contains the highly conserved chromodomain and carboxy-terminal COOH box of other known Pc proteins from diverse species. Like other Pc proteins, MPc3 physically interacts with the RING finger proteins RING1A and dinG/RING1B. MPc3 maps to the distal arm of mouse chromosome 11 (11E2), a region that contains other known Pc genes in addition to several disease loci that may be linked to abnormal Pc gene function.
