Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The central nervous system and HRT.

S Palacios1, I Cifuentes, C Menendez

  • 1Instituto Palacios de Salud de la Mujer, Madrid, Spain.

International Journal of Fertility and Women'S Medicine
|March 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Nutraceuticals in the clinical management of women with breast cancer; a narrative review].

Semergen·2026
Same author

[Recommendations for the management of menopausal vasomotor symptoms in clinical practice].

Semergen·2025
Same author

Management of menopausal hot flushes. Recommendations from the Spanish Menopause Society.

European journal of obstetrics & gynecology and reproductive biology: X·2025
Same author

Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.

European review for medical and pharmacological sciences·2023
Same author

Sequential treatment in vulvovaginal atrophy.

Climacteric : the journal of the International Menopause Society·2023
Same author

10-month retrospective study on compliance and tolerability of the drospirenone-only pill.

European review for medical and pharmacological sciences·2023

Hormonal replacement therapy (HRT) may reduce Alzheimer's disease (AD) risk in postmenopausal women. More research is needed to confirm HRT's cognitive benefits and AD risk reduction.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Postmenopausal hypoestrogenism and aging are linked to cognitive decline and increased Alzheimer's disease (AD) risk.
  • Estrogen deficiency significantly impacts cognitive functions in aging women.

Purpose of the Study:

  • To review the potential benefits of hormonal replacement therapy (HRT) on cognitive function.
  • To evaluate the impact of HRT on the risk of developing Alzheimer's disease (AD).

Main Methods:

  • Systematic review of MEDLINE database.
  • Analysis of references from existing reviews on HRT, cognition, and AD.
  • Evaluation of epidemiological studies, including case-control designs.

Main Results:

Related Experiment Videos

  • Epidemiological studies on HRT and cognitive function show mixed results, potentially due to methodological variations.
  • Available data suggest a possible association between HRT use and a reduced risk of Alzheimer's disease (AD).

Conclusions:

  • The potential protective effect of HRT against AD requires cautious interpretation due to study limitations, particularly bias in case-control studies.
  • Further rigorous clinical trials and longitudinal studies are essential to definitively establish the effects of estrogen therapy on cognition and AD prevention.