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A pilot study evaluating the treatment of postparotidectomy sialoceles with botulinum toxin type A
H Vargas1, L T Galati, S M Parnes
1Division of Otolaryngology--Head and Neck Surgery, Department of Surgery, Albany Medical College, NY 12208, USA.
Objective:
To report our experience in treating 4 cases of recurrent siacloceles with botulinum toxin type A after partoid surgery.
Design:
This is a prospective, nonrandomized, nonblinded pilot study describing a new use for botulinum toxin type A.
Setting:
Tertiary academic medical center.
Patients:
Four patients (2 men and 2 women) with persistent postparotidectomy sialoceles who had undergone various treatment failures were included. The diagnosis was made by fine-needle aspiration of the mass based on well-recognized cytologic features of the entity, as well as an elevated amylase level and no evidence of tumor or infection.
Interventions:
Sialoceles were aspirated before local injection of botulinum toxin type A (30-50 U) subcutaneously.
Main Outcome Measures:
The patients were followed up 1 week after receiving botulinum toxin type A injection and then at monthly intervals. They were extensively questioned and examined for any evidence of side effects or recurrence.
Results:
All patients had total resolution of sialocele or external salivary fistula within 1 month of treatment. None of the patients to date have demonstrated recurrences at 7 through 13 months, and there were no complications, particularly facial nerve weakness.
Conclusion:
Our findings suggested that botulinum toxin type A offers a highly effective, safe, and noninvasive method of treatment in postparotidectomy sialocele.
