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Polymicrobial septic arthritis due to Clostridium species: case report and review
C M Gredlein1, M L Silverman, M S Downey
1Division of Podiatric Surgery, Presbyterian Medical Center of the University of Pennsylvania Health System, Philadelphia, PA 19104-2699, USA. cgredlein@aol.com
Abstract:
Clostridium species are capable of producing several types of infectious processes, many of which have proven to be life-threatening. Septic arthritis caused by Clostridium, however, is not a very frequent finding. Currently, only 37 cases of infectious arthritis due to Clostridium species have been reported. We report a case of septic arthritis in which Clostridium perfringens, Clostridium sordellii, and Clostridium tertium were each isolated from the synovial aspirate. In addition, the 37 previously reported cases are summarized to compare the similarities and differences of the clinical course, treatment, and outcome, in order to help establish guidelines for the proper management of this infectious process.
Insights
Clostridium species rarely cause septic arthritis, a severe joint infection. This study reports a rare case involving three Clostridium species and reviews 37 prior cases to guide management.
Area of Science:
- Microbiology
- Infectious Diseases
- Rheumatology
Background:
- Clostridium species can cause life-threatening infections.
- Septic arthritis due to Clostridium is a rare clinical finding, with only 37 cases previously reported.
- This study addresses the infrequent occurrence of Clostridium-induced septic arthritis.
Observation:
- A rare case of septic arthritis is presented, involving simultaneous isolation of Clostridium perfringens, Clostridium sordellii, and Clostridium tertium from synovial fluid.
- This case highlights the potential for polymicrobial Clostridium infections in septic arthritis.
Findings:
- A comprehensive review and summary of 37 previously reported cases of Clostridium-induced septic arthritis were conducted.
- Analysis focused on comparing clinical presentations, treatment strategies, and patient outcomes across documented cases.
Implications:
- The findings aim to contribute to establishing evidence-based guidelines for managing Clostridium septic arthritis.
- Understanding the clinical course and outcomes can improve diagnostic and therapeutic approaches for this rare condition.