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Intermolecular V(D)J recombination

A Tevelev1, D G Schatz

  • 1Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.

The Journal of Biological Chemistry
|March 18, 2000
PubMed
Summary

V(D)J recombination can occur between separate DNA molecules, forming coding joints. Linearization of substrates unexpectedly reduces coding joint formation, suggesting a "release and recapture" mechanism.

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