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New cytotoxic agents, BE-54238A and B, produced by a streptomycete
M Tsukamoto1, S Nakajima, K Murooka
1Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Japan.
The Journal of Antibiotics
|March 21, 2000
Abstract:
New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activity against murine and human tumor cell lines.