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Formulation of trichloroacetic acid peeling solution: a bibliometric analysis
M Vossen1, J J Hage, R B Karim
1Department of Plastic and Reconstructive Surgery at the Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
Plastic and Reconstructive Surgery
|March 21, 2000
Summary
Trichloroacetic acid (TCA) solutions for chemical peels vary widely in concentration depending on preparation method. Most studies fail to report the TCA formula, hindering result evaluation and complication prevention.
Area of Science:
- Dermatology
- Cosmetic Science
- Chemical Engineering
Background:
- Trichloroacetic acid (TCA) solutions are widely used for chemical exfoliation and skin peels.
- The preparation of TCA solutions can follow four distinct formulas, leading to significant variations in actual concentration.
Purpose of the Study:
- To analyze the reporting of trichloroacetic acid (TCA) solution formulas in scientific literature.
- To highlight the importance of reporting TCA concentration and preparation methods for accurate clinical application and research.
Main Methods:
- A comprehensive review of 120 publications on trichloroacetic acid (TCA) peeling since 1926 was conducted.
- Analysis included identifying whether the formula for TCA solution preparation was reported by authors.
Main Results:
- Only 27% of reviewed publications reported the specific formula used for trichloroacetic acid (TCA) solutions.
- Reported 50% TCA solutions varied from 40% to 71% in actual weight-to-volume concentration.
- Major pharmacopeias also lack standardized formulas for TCA solutions.
Conclusions:
- Inconsistent reporting of trichloroacetic acid (TCA) solution formulas compromises the reproducibility and safety of chemical peels.
- Standardized reporting of TCA concentration and preparation methods is crucial for reliable clinical outcomes and complication management.