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Cerebral laterality in adolescent major depression.

D S Pine1, L M Kentgen, G E Bruder

  • 1Division of Child Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 74, New York, NY 10032-3784, USA. pined@child.cpmc.columbia.edu

Psychiatry Research
|March 22, 2000
PubMed
Summary

Adolescents and adults with major depression show altered brain asymmetry, particularly in language processing. Comorbid anxiety disorders modify these cerebral lateralization patterns differently across age groups.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Major depression is associated with altered cerebral asymmetry in adults.
  • Understanding developmental trajectories of cerebral lateralization in adolescent depression is crucial.

Purpose of the Study:

  • To investigate if adolescents with major depression exhibit cerebral asymmetry abnormalities similar to adults.
  • To examine the influence of comorbid anxiety disorders on cerebral asymmetry in depressed adolescents and adults.

Main Methods:

  • Assessed perceptual asymmetry using verbal and non-verbal dichotic listening tasks in four groups: depressed adolescents, adolescent comparisons, depressed adults, and adult comparisons.
  • Data collection procedures were identical for adolescents and adults.
  • Subjects with major depression were subgrouped based on the presence or absence of anxiety disorders.

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Main Results:

  • Both depressed and healthy adolescents and adults showed expected perceptual asymmetry for dichotic tasks.
  • Depressed individuals exhibited an increased right ear/left hemisphere advantage for fused words compared to controls.
  • Comorbid anxiety disorders modulated this effect differently in adults (reduced advantage) versus adolescents (no significant change).

Conclusions:

  • Findings suggest both developmental similarities and differences in the relationship between cerebral lateralization and psychopathology.
  • Cerebral asymmetry patterns in major depression are influenced by age and comorbid anxiety disorders.
  • Further longitudinal and family-based studies are needed to clarify associations between cerebral laterality and psychopathology across development.