Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated tissue factor levels in leukemic cell homogenate.

T Nakasaki1, H Wada, R Watanabe

  • 1Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Japan.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|March 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis.

Gene therapy·2017
Same author

Enhanced wound healing by topical application of ointment containing a low concentration of povidone-iodine.

Journal of wound care·2016
Same author

Protein S is protective in pulmonary fibrosis.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Circulating fibrocytes correlate with the asthma control test score.

Allergologia et immunopathologia·2016
Same author

Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.

Leukemia·2015
Same author

Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.

Journal of thrombosis and haemostasis : JTH·2014
Same journal

Association of Protein C, but Not Protein S or Antithrombin With Ischemic Stroke: Bidirectional Two-Sample Mendelian Randomization and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Risk Prediction Models for Deep Vein Thrombosis in Patients With Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Efficacy of an Integrated Nursing Protocol for the Management of Postoperative Upper Limb Circulatory Complications Following Transradial Coronary Intervention.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Dual-Channel Inhibition With Rivaroxaban and Aspirin for Thromboprophylaxis in Patients With Long-Term Inferior Vena Cava Filter Implantation: A Two-Center Cohort Study.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Interpretation of Prothrombin Time and Activated Partial Thromboplastin Time Mixing Studies Using Predefined Algorithms.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
See all related articles

Tissue factor (TF) is elevated in leukemia cells, particularly acute promyelocytic leukemia (APL). Higher TF levels in leukemia correlate with disseminated intravascular coagulation (DIC), suggesting TF measurement can predict DIC risk.

Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Background:

  • Tissue factor (TF) plays a crucial role in hemostasis and thrombosis.
  • Elevated TF expression is implicated in various hematological malignancies.
  • Understanding TF levels in leukemia is important for predicting complications like DIC.

Purpose of the Study:

  • To quantify Tissue Factor (TF) antigen and activity in leukemic cell homogenates.
  • To compare TF levels between different types of leukemia and healthy controls.
  • To investigate the correlation between TF levels and disseminated intravascular coagulation (DIC) in leukemia patients.

Main Methods:

  • Measurement of TF antigen and TF activity in leukemic cell homogenates.
  • Comparison of TF levels in acute promyelocytic leukemia (APL), myelocytic leukemia, and lymphocytic leukemia cells.

Related Experiment Videos

  • Assessment of TF levels in patients with and without DIC.
  • Investigation of the role of phospholipids in TF activity.

    • Main Results:

    • Significantly higher TF antigen and activity were observed in leukemic cells compared to healthy controls, especially in APL.
    • Myelocytic leukemia cells exhibited higher TF antigen and activity than lymphocytic leukemia cells.
    • A strong correlation was found between TF antigen and TF activity in leukemic cells.
    • The TF activity/TF antigen ratio was higher in myelocytic leukemia than in lymphocytic leukemia.
    • TF levels and the TF activity/TF antigen ratio were significantly elevated in leukemia patients with DIC.

    Conclusions:

    • Leukemic cells, particularly APL, show increased TF antigen and activity.
    • TF levels in leukemic cells are a potential biomarker for predicting DIC.
    • The findings highlight the clinical relevance of TF in leukemia management.