Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Disseminated intravascular coagulation].

M Levi1, E de Jonge, H ten Cate

  • 1Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde en afd. Intensive Care, Amsterdam.

Nederlands Tijdschrift Voor Geneeskunde
|March 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From prediction to practice: early implementation of a machine learning-based hospitalization prediction tool in the emergency department.

International journal of medical informatics·2026
Same author

Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire.

BMC geriatrics·2026
Same author

Predicting clinically relevant bleeding in new-onset atrial fibrillation patients initiating oral anticoagulant therapy: External validation of the AF-BLEED score.

Thrombosis research·2025
Same author

Atypical Resting-State EEG Graph Metrics of Network Efficiency Across Development in Autism and Their Association with Social Cognition: Results from the LEAP Study.

Journal of autism and developmental disorders·2025
Same author

Oxygen consumption, effort, and weaning in the mechanically ventilated patient in the intensive care unit: The extubate study: A protocol for an observational study.

Respiratory medicine·2025
Same author

Transvaginal uterine niche repair: surgical technique and outcome.

Facts, views & vision in ObGyn·2024
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Disseminated intravascular coagulation (DIC) involves widespread blood clotting that impairs organ function and bleeding due to factor consumption. Understanding DIC pathogenesis aids in developing better treatments, including anticoagulants and transfusions.

Area of Science:

  • Hematology
  • Pathophysiology
  • Internal Medicine

Context:

  • Disseminated intravascular coagulation (DIC) is a complex syndrome with systemic activation of coagulation.
  • It leads to thrombus formation, impaired organ perfusion, and potential bleeding due to consumption of platelets and clotting factors.
  • DIC is associated with various conditions including infections, trauma, malignancies, and obstetrical complications.

Purpose:

  • To elucidate the underlying mechanisms of disseminated intravascular coagulation.
  • To provide a foundation for improved therapeutic strategies for patients experiencing DIC.

Summary:

  • DIC is characterized by excessive thrombin generation, suppressed anticoagulant pathways, and inhibited fibrinolysis, leading to systemic fibrin deposition.
  • This complex interplay results in both thrombotic events and a hemorrhagic diathesis.

Related Experiment Videos

  • The condition arises from diverse triggers, highlighting its systemic nature.

    • Impact:

    • Enhanced understanding of DIC pathogenesis facilitates the development of targeted and effective management approaches.
    • Potential therapies include anticoagulants, platelet and plasma transfusions, coagulation factor concentrates, and antifibrinolytic agents.
    • Improved management strategies aim to mitigate the severe consequences of DIC, improving patient outcomes.