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Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
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Apnoeic attacks as an isolated manifestation of epileptic seizures in infants

G P Ramelli1, F Donati, M Bianchetti

  • 1Department of Pediatrics, University of Berne, Switzerland.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|March 22, 2000
PubMed

Insights

Infants can experience seizures presenting solely as apnoea (cessation of breathing). This study documents four such cases, highlighting the importance of electroencephalogram (EEG) for diagnosis and treatment in infants.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Apnoea is a recognized seizure manifestation in neonates.
  • Seizure-induced apnoea is less commonly observed in infants.

Observation:

  • Four infants presented with apnoea as the sole seizure symptom.
  • Apnoea onset occurred between 2-11 months of age.
  • Polygraphic ictal electroencephalogram (EEG) and video recording confirmed seizures.

Findings:

  • Interictal EEG was normal in all cases.
  • Ictal EEG revealed focal rhythmic alpha or theta activity, sometimes generalizing, lasting 40-120 seconds.
  • Apnoea began shortly after rhythmic EEG activity; heart rate remained stable.

Implications:

  • Highlights the diagnostic value of EEG in infant apnoea.
  • Suggests prompt anti-epileptic therapy can lead to seizure freedom and normal development.
  • Underscores the potential for severe developmental outcomes with untreated or refractory seizures.

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