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Ultrastructural pathogenesis of the PRRS virus
1Pharmacia & Upjohn, Barcelona, Spain. paloma.suarez@eu.pnu.com
Veterinary Research
|March 22, 2000
Summary
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) induces apoptosis in cells, potentially through a bystander mechanism affecting cells not infected by the virus. This review examines the ultrastructural pathogenesis of PRRSV.
Area of Science:
- Veterinary Virology
- Cell Biology
- Pathogenesis
Background:
- Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a significant swine pathogen.
- PRRSV replicates in swine alveolar macrophages (SAMs) and other cell types via receptor-mediated endocytosis.
- PRRSV is known to induce apoptosis both in vivo and in vitro.
Purpose of the Study:
- To review the ultrastructural pathogenesis of PRRSV.
- To explore the mechanisms of PRRSV-induced apoptosis.
- To discuss the potential bystander effect of PRRSV-induced apoptosis.
Main Methods:
- Literature review of ultrastructural studies on PRRSV.
- Analysis of cellular changes following PRRSV infection.
- Examination of evidence for PRRSV-induced apoptosis.
Main Results:
- PRRSV entry involves receptor-mediated endocytosis.
- PRRSV infection leads to significant cellular alterations.
- Apoptosis induction by PRRSV is a key pathogenic feature, possibly acting via bystander effects.
Conclusions:
- PRRSV pathogenesis involves complex ultrastructural changes.
- The apoptotic-inducing nature of PRRSV, including bystander effects, is crucial to its pathology.
- Further research into PRRSV's molecular mechanisms is warranted.