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Aujeszky's disease virus: opportunities and challenges
1Department of Veterinary Pathobiology, University of Illinois, Urbana 61801, USA. fazaaa@uiuc.edu
Veterinary Research
|March 22, 2000
Summary
Aujeszky's disease virus (ADV) research has advanced swine vaccine development and illuminated the porcine immune system. Studies using ADV have provided insights into both viral disease control and immune response mechanisms in pigs.
Area of Science:
- Veterinary Virology
- Immunology
- Swine Infectious Diseases
Background:
- Aujeszky's disease (AD), caused by Aujeszky's disease virus (ADV), is a significant viral disease in swine.
- ADV is a neurotropic alphaherpesvirus causing severe encephalitis in young pigs and milder symptoms in adults.
Purpose of the Study:
- To review research utilizing ADV as a model for novel swine vaccine development.
- To summarize findings on the porcine immune response to ADV infection and vaccination.
Main Methods:
- Literature review of studies involving Aujeszky's disease virus.
- Analysis of research on vaccine concepts and immune responses in swine.
Main Results:
- ADV has been instrumental in testing innovative vaccine strategies, including the first field-used genetically modified vaccine.
- Research on ADV has yielded crucial information regarding the porcine immune system, notably the humoral-cellular immune response dichotomy.
Conclusions:
- Aujeszky's disease virus serves as a valuable tool for advancing swine vaccine technology.
- Understanding ADV has significantly contributed to comprehending swine immune responses to infectious agents.