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Choroidal Langerhans' cell histiocytosis
1Department of Ophthalmology, School of Medicine, Kyungpook National University, Taegu, South Korea.
Acta Ophthalmologica Scandinavica
|March 22, 2000
Summary
This study reports a rare case of choroidal Langerhans' cell histiocytosis in a male patient. Diagnostic imaging and histopathology confirmed the localized ocular tumor without systemic involvement.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Langerhans' cell histiocytosis (LCH) is a rare clonal proliferative disorder.
- Ocular involvement in LCH can manifest in various forms, including choroidal tumors.
Observation:
- A 49-year-old male presented with a solitary choroidal tumor and visual disturbances.
- Diagnostic imaging included ultrasonography, fluorescein angiography, and indocyanine green angiography.
- The eyeball was enucleated for detailed histopathological examination.
Findings:
- Fluorescein angiography showed mottled hyperfluorescence and late-phase hyperfluorescence.
- Indocyanine green angiography revealed hypofluorescence.
- Microscopic examination confirmed extensive choroidal infiltration by histiocytes.
- Immunohistochemistry (S-100, CD 68) and electron microscopy (Birbeck granules) were characteristic of LCH.
Implications:
- This case highlights the importance of considering LCH in the differential diagnosis of choroidal tumors.
- Accurate diagnosis through advanced imaging and histopathology is crucial for appropriate management.
- The absence of systemic lesions in this case suggests a potential for localized ocular presentation of LCH.