Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contact allergy, irritancy and 'danger'.

J P McFadden1, D A Basketter

  • 1St John's Institute of Dermatology, St Thomas's Hospital, London, UK.

Contact Dermatitis
|March 22, 2000
PubMed
Summary

The danger model offers a new perspective on allergic contact dermatitis, suggesting immune activation requires both antigen and irritant signals. This explains sensitization and hypersensitivity, differing from traditional self/non-self immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Ion Fluxes at Mars: First Results of Tailward Flows From MAVEN-STATIC.

Journal of geophysical research. Space physics·2022
Same author

In Situ Measurements of Thermal Ion Temperature in the Martian Ionosphere.

Journal of geophysical research. Space physics·2022
Same author

Synergistic multiple early therapy (SMET) for inflammatory diseases with pathogenic autoinflammatory feedback circuits.

The British journal of dermatology·2021
Same author

Identifying Ultra Low Frequency Waves in the Lunar Plasma Environment Using Trajectory Analysisand Resonance Conditions.

Journal of geophysical research. Space physics·2021
Same author

Solar Wind and Interplanetary Magnetic Field Influence on Ultralow Frequency Waves and Reflected Ions Near the Moon.

Journal of geophysical research. Space physics·2021
Same author

A Tenuous Lunar Ionosphere in the Geomagnetic Tail.

Geophysical research letters·2021

Area of Science:

  • Immunology
  • Dermatology
  • Allergenicity

Background:

  • Traditional immune models focus on self vs. non-self recognition.
  • Allergic contact dermatitis (ACD) involves immune responses to haptens.
  • Existing models do not fully explain ACD induction and elicitation.

Purpose of the Study:

  • To evaluate the 'danger' model as an alternative framework for understanding ACD.
  • To propose that cutaneous irritancy acts as a 'danger' signal in ACD.
  • To explain ACD pathogenesis, including sensitization and hypersensitivity, using the danger model.

Main Methods:

  • Conceptual analysis applying the 'danger' model to ACD.
  • Comparison of danger model predictions with existing observations in ACD.
  • Hypothesizing the role of irritancy as a danger signal in ACD.

Main Results:

  • The danger model posits that immune activation in ACD requires both antigenic and 'danger' signals (e.g., irritancy).
  • Antigenic signals alone may lead to tolerance, while combined signals trigger sensitization and hypersensitivity.
  • Irritancy, often concentration-dependent, is proposed as the primary danger signal, influencing effective hapten concentrations.

Conclusions:

  • The danger model provides a compelling alternative to self/non-self paradigms for ACD.
  • Cutaneous irritancy is identified as a critical 'danger' signal in ACD.
  • The model explains low-dose tolerance phenomena by the absence of irritant effects at lower allergen concentrations.

Related Experiment Videos