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A new cause of 'non-responsiveness' in coeliac disease?
J S Jennings1, J I Wyatt, P D Howdle
1Division of Medicine, St James's University Hospital, Leeds, UK.
Postgraduate Medical Journal
|March 23, 2000
Abstract:
A 42 year old man presented with gluten-responsive coeliac disease and secondary pancreatic insufficiency. Subsequently his symptoms relapsed and repeat small intestinal biopsy showed villous atrophy and infiltration by leukaemic cells, despite continuation of a gluten-free diet. Serious causes of relapse and non-responsiveness in coeliac disease include enteropathy-associated T-cell lymphoma, ulcerative jejunitis and an end-stage hypoplastic mucosa. This is the first report of non-responsiveness due to infiltration by leukaemia.