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The cortical vibrissae representation is normal in transgenic mice lacking the 5-HT(1B) receptor
C B Boylan1, K L Kesterson, T A Crnko-Hoppenjans
1Department of Anatomy and Neurobiology, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH, USA. cboylan@mco.edu
Brain Research. Developmental Brain Research
|March 23, 2000
Abstract:
Recent studies have suggested that 5-HT may modulate thalamocortical development in somatosensory cortex (S-I) of rats and mice, and that the 5-HT(1B) receptor may play a critical role in this process. Analysis of CO-stained sections through lamina IV of S-I in perinatal and adult 5-HT(1B) knockout mice revealed a normal vibrissae-related pattern, indicating that activation of the 5-HT(1B) receptor is not necessary for the normal development of the vibrissae representation in S-I.