Polycyclic diterpenoids from Euphorbia characias
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Updated: Oct 17, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
G Appendino1, E Belloro, G C Tron
1Dipartimento di Scienza e Tecnologia del Farmaco, Via Giuria 9, I-10125 Torino, Italy. appendin@pharm.unito.it
Abstract:
In addition to widespread flavonoids, a collection of Euphorbia characias from Sardinia afforded 13 oxygenated diterpenoids of the atisane, abietane, pimarane, and kaurane type. Four of these compounds (1, 3a, 7a,b) are new. The accumulation of substantial amounts of biologically active diterpenoids of limited availability, like ent-atisanes endowed with anti-HIV activity and ent-abietanolides active on the central nervous system, makes E. characias an interesting source of lead compounds for biomedical research.
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