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Cytotoxicity and antileishmanial activity of Annona muricata pericarp
M C Jaramillo1, G J Arango, M C González
1Facultad de Química Farmacéutica, Universidad de Antioquia, A. A. 1226 Medellín, Colombia.
Fitoterapia
|March 23, 2000
Abstract:
Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937. The ethyl acetate extract was more active than the other extracts and even of Glucantime used as reference substance. Its fractionation led to the isolation of three acetogenins--annonacin, annonacin A and annomuricin A.