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Clinico-immunological profile of juvenile rheumatoid arthritis at Chandigarh
1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
Objective:
To study the clinical and immunological profile of children with juvenile rheumatoid arthritis (JRA).
Design:
Retrospective hospital based study.
Setting:
Tertiary level center of North India.
Subjects:
74 patients attending the Pediatric Rheumatology and Immunology Clinic over last 5 years.
Results:
The patients were aged between 9 months to 12 years with male female ratio of 1.8:1. Eleven (14.9%) patients had systemic onset JRA, 28 (37.8%) had polyarticular onset type and 35(47.3%) had pauciarticular onset type JRA. Uveitis was present only in one patient and rheumatoid nodules were present in 4(5.4%) patients. Rheumatoid factor was positive in 2(2.7%) and antinuclear antibody was present in one patient only. HLA-B27 was positive in 4 children. Two patients developed amyloidosis.
Conclusion:
The clinico-immunological profile of JRA at Chandigarh appears to be some what different from that reported from other centers in India.