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Related Experiment Videos

Does the brain regenerate after perinatal infarction?

M A Rutherford1, J M Pennock, F M Cowan

  • 1Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|January 1, 1997
PubMed
Summary

Brain growth after perinatal infarction shows significant recovery. Undamaged brain tissue can grow into the infarcted area, aiding in the developing brain

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Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Perinatal infarction can impact infant brain development.
  • Assessing brain growth post-infarction is crucial for understanding recovery.

Purpose of the Study:

  • To evaluate brain growth following perinatal infarction in infants.
  • To investigate the role of brain plasticity in recovery.

Main Methods:

  • Serial magnetic resonance imaging (MRI) scans were used.
  • Three-dimensional volume acquisition and image registration were performed.
  • Image subtraction quantified brain growth between scans.

Main Results:

  • Early infarction showed low signal areas with defined margins.

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  • Later, brain growth occurred at infarct margins, reducing infarct size.
  • Growth rates into the infarcted area varied compared to surrounding brain.

    • Conclusions:

    • Brain growth into infarcted areas is a key recovery mechanism.
    • Undamaged tissue growth may facilitate neuroplasticity and functional recovery.
    • This study highlights the brain's adaptive capacity after perinatal injury.