Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatocellular carcinoma.

K Okuda1

  • 1Department of Medicine, Chiba University School of Medicine, Japan.

Journal of Hepatology
|March 23, 2000
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) is rising globally, linked to hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. Understanding HCC

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case report of double bile duct].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·1992
Same author

[Clinical effects of six-month short time biofiltration].

Nihon Jinzo Gakkai shi·1992
Same author

[Historical aspects of clinical enzymology].

Rinsho byori. The Japanese journal of clinical pathology·1992
Same author

The relationship between polysaccharide antigen and interleukin-1 beta producing activity in Porphyromonas gingivalis.

The Bulletin of Tokyo Dental College·1992
Same author

Diagnosis of typhus infection with Rickettsia tsutsugamushi by polymerase chain reaction.

Journal of medical microbiology·1992
Same author

Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase.

The Journal of biological chemistry·1992
Same journal

Durvalumab with gemcitabine-based chemotherapy regimens in advanced biliary tract cancer: primary results from the phase IIIb TOURMALINE study.

Journal of hepatology·2026
Same journal

Reply to "Role of HBV genotype, monitoring, and events after cessation of nucleos(t)ide analogue therapy".

Journal of hepatology·2026
Same journal

When Biology Pushes Back: Lessons From HBsAg-Targeting Therapies in Hepatitis Delta.

Journal of hepatology·2026
Same journal

Moving Too Fast? A Meta-Analysis Calls for Caution on TNF Inhibitors as First-Line Therapy for Autoimmune Hepatitis.

Journal of hepatology·2026
Same journal

Anserine restores antibacterial immunity in cirrhosis via a protective CCL5-mediated hepatocyte-CD44<sup>+</sup>pDC crosstalk.

Journal of hepatology·2026
Same journal

Anti-CCL2-conjugated platelets attenuate early allograft and ischemia-reperfusion injury by inhibiting monocyte infiltration.

Journal of hepatology·2026
See all related articles

Area of Science:

  • Hepatology and Oncology
  • Viral Hepatitis and Carcinogenesis
  • Molecular Biology and Diagnostics

Background:

  • Increasing global incidence of Hepatocellular Carcinoma (HCC), particularly linked to Hepatitis C Virus (HCV) infections.
  • Varied HCC epidemiology worldwide and conflicting data on post-transfusion non-A, non-B hepatitis.
  • Limited understanding of the genetic basis of hepatocarcinogenesis and environmental chemical carcinogens beyond aflatoxins.

Purpose of the Study:

  • To explore the epidemiology and genetic basis of Hepatocellular Carcinoma (HCC).
  • To investigate the molecular mechanisms of HCC associated with Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).
  • To highlight challenges in pathological and clinical diagnosis and emphasize the need for improved diagnostic techniques and prevention strategies.

Related Experiment Videos

Main Methods:

  • Review of existing observations on HCC epidemiology and genetic factors.
  • Analysis of molecular mechanisms involving HBV X gene, p53 mutations, and HCV proteins (core, NS3).
  • Evaluation of diagnostic advancements including imaging, des-gamma-carboxy prothrombin (PIVKA II) assay, and AFP lectin affinity chromatography.

Main Results:

  • Hepatitis B Virus (HBV) associated HCC may involve p53 codon 249 mutation linked to aflatoxin exposure and the HBV X gene.
  • Hepatitis C Virus (HCV) associated HCC shows preliminary molecular mechanisms, including HCV core protein inducing HCC in transgenic mice.
  • Current pathological and clinical diagnostic methods for early HCC detection remain unsatisfactory, necessitating advanced biochemical and imaging techniques.

Conclusions:

  • Early diagnosis and liver transplantation are current best treatments for HCC, but donor shortage limits availability.
  • Despite resection, recurrence is common, underscoring the critical need for HCC prevention strategies, including viral hepatitis prevention and chemoprevention.
  • Further research into the genetic basis, molecular mechanisms, and effective chemoprevention is essential to combat the rising incidence of Hepatocellular Carcinoma.