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Memory in viral quasispecies.

C M Ruiz-Jarabo1, A Arias, E Baranowski

  • 1Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Journal of Virology
|March 23, 2000
PubMed
Summary
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Evolving viral quasispecies exhibit molecular memory through minority variants, influencing their response to selective pressures. This viral memory, unseen in consensus sequences, reveals a deeper evolutionary history impacting viral adaptation.

Area of Science:

  • Virology
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Biological adaptive systems, like the immune system, often possess memory of past events.
  • Evolving viral populations (quasispecies) are known for variation and information continuity.

Purpose of the Study:

  • To provide direct evidence of molecular memory in evolving viral quasispecies.
  • To investigate how past evolutionary history influences viral population dynamics under selective constraints.

Main Methods:

  • Experiments utilized foot-and-mouth disease virus populations with documented evolutionary histories.
  • Analysis focused on the composition and behavior of viral populations under selective pressure.
  • Comparison of viral response to predictions based solely on consensus nucleotide sequences.

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Main Results:

  • Evolving viral quasispecies demonstrated molecular memory, existing as minority variants within their mutant spectra.
  • Past evolutionary history significantly influenced the viral population's composition and behavior.
  • This influence on viral response to selection could not be predicted from consensus sequences alone.

Conclusions:

  • Viral quasispecies possess a molecular memory mechanism, mediated by minority sequence variants.
  • This memory impacts both the nature and intensity of the viral response to selective constraints.
  • Understanding viral molecular memory is crucial for predicting viral evolution and adaptation.