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Fibrinogen, angina and coronary heart disease in a Chinese population

T H Lam1, L J Liu, E D Janus

  • 1Department of Community Medicine, The University of Hong Kong, Patrick Manson Building South Wing, 7 Sassoon Road, Hong Kong, PR China. hrmrlth@hkucc.hku.hk

Atherosclerosis
|March 24, 2000
PubMed

Insights

Fibrinogen is a significant risk factor for coronary heart disease (CHD) in the Chinese population. Higher fibrinogen levels correlate with increased CHD severity in both men and women.

Area of Science:

  • Cardiovascular Research
  • Epidemiology
  • Biochemistry

Background:

  • Fibrinogen is a known risk factor for coronary heart disease (CHD).
  • The association between fibrinogen and CHD in the Chinese population remains unclear.
  • This study investigates the relationship in Hong Kong Chinese.

Purpose of the Study:

  • To analyze the association between fibrinogen levels and coronary heart disease (CHD) in Hong Kong Chinese.
  • To determine if fibrinogen is a significant risk factor for CHD in this demographic.

Main Methods:

  • Population-based cross-sectional study.
  • Inclusion of 1348 men and 1385 women aged 25-74 years.
  • Fibrinogen measurement using the Clauss method; CHD severity categorized.

Main Results:

  • Elevated fibrinogen levels were observed in subjects with angina and diagnosed CHD compared to controls.
  • Significant positive association between fibrinogen concentration and CHD severity in both men and women (P<0.01).
  • Associations remained significant after adjusting for other cardiovascular risk factors.

Conclusions:

  • Fibrinogen should be considered a significant risk factor for coronary heart disease (CHD) in the Chinese population.
  • The findings support the role of fibrinogen in the pathogenesis of CHD among Chinese individuals.
  • Further research may explore targeted interventions based on fibrinogen levels.

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