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Fibrinogen, angina and coronary heart disease in a Chinese population
1Department of Community Medicine, The University of Hong Kong, Patrick Manson Building South Wing, 7 Sassoon Road, Hong Kong, PR China. hrmrlth@hkucc.hku.hk
Insights
Fibrinogen is a significant risk factor for coronary heart disease (CHD) in the Chinese population. Higher fibrinogen levels correlate with increased CHD severity in both men and women.
Area of Science:
- Cardiovascular Research
- Epidemiology
- Biochemistry
Background:
- Fibrinogen is a known risk factor for coronary heart disease (CHD).
- The association between fibrinogen and CHD in the Chinese population remains unclear.
- This study investigates the relationship in Hong Kong Chinese.
Purpose of the Study:
- To analyze the association between fibrinogen levels and coronary heart disease (CHD) in Hong Kong Chinese.
- To determine if fibrinogen is a significant risk factor for CHD in this demographic.
Main Methods:
- Population-based cross-sectional study.
- Inclusion of 1348 men and 1385 women aged 25-74 years.
- Fibrinogen measurement using the Clauss method; CHD severity categorized.
Main Results:
- Elevated fibrinogen levels were observed in subjects with angina and diagnosed CHD compared to controls.
- Significant positive association between fibrinogen concentration and CHD severity in both men and women (P<0.01).
- Associations remained significant after adjusting for other cardiovascular risk factors.
Conclusions:
- Fibrinogen should be considered a significant risk factor for coronary heart disease (CHD) in the Chinese population.
- The findings support the role of fibrinogen in the pathogenesis of CHD among Chinese individuals.
- Further research may explore targeted interventions based on fibrinogen levels.
Abstract:
Although fibrinogen is an established risk factor of coronary heart disease (CHD), whether fibrinogen is associated with CHD in Chinese is not clear. This population-based cross-sectional study aimed to analyse this relationship in Hong Kong Chinese. Fibrinogen was measured by the Clauss method in 1348 men and 1385 women aged 25-74 years. Severity of CHD was defined as most serious if the subjects had medically diagnosed CHD, as less serious if they had angina only, and as normal if they had neither. The prevalence of angina and CHD was respectively 2.4% and 2.2% in men and 3.2% and 2.7% in women. In men the age-adjusted mean fibrinogen concentration was 2.47 (95% confidence interval (CI) 2.43-2.51) g/l in the normal group, 2.65 (95% CI 2.45-2.85) g/l in the angina group, and 2.78 (95% CI 2.56-3. 00) g/l in the CHD cases (P<0.01); in women it was respectively 2.61 (95% CI 2.59-2.63), 2.66 (95% CI 2.50-2.82), 2.90 (95% CI 2.72-3.08) g/l (P<0.01). The differences were significant after adjustment of other significant risk factors. We conclude that fibrinogen should be considered as a risk factor in Chinese.