Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do central nervous system axons remyelinate?

B Nait-Oumesmar1, F Lachapelle, L Decker

  • 1Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York 10029-6574, USA.

Pathologie-Biologie
|March 24, 2000
PubMed
Summary

Remyelination in multiple sclerosis (MS) is often incomplete due to cell exhaustion or a non-permissive environment. Identifying endogenous oligodendrocyte precursor cells could enhance myelin repair strategies for MS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Effects of Communities That Care on the Adoption and Implementation Fidelity of Evidence-Based Prevention Programs in Communities: Results from a Quasi-experimental Study.

Prevention science : the official journal of the Society for Prevention Research·2025
Same author

[Diagnosis and treatment of ANCA-associated vasculitis : S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for ENT Medicine and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
Same author

[Diagnosis and treatment of ANCA-associated vasculitis : SHORT VERSION of the S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for Otorhinolaryngology and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
Same author

Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.

Nature communications·2024
Same author

Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2021
Same author

Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS.

Frontiers in cellular neuroscience·2020

Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) involves incomplete remyelination of demyelinating lesions in the central nervous system (CNS).
  • The CNS possesses endogenous mechanisms for oligodendrocyte renewal, indicating regenerative potential.
  • Inefficient remyelination may stem from depleted cell pools, axonal damage, or an unfavorable environment.

Purpose of the Study:

  • To identify the cell types responsible for generating new oligodendrocytes for remyelination.
  • To explore strategies for activating these endogenous cells to enhance myelin repair.
  • To understand the mechanisms governing oligodendrocyte precursor cell proliferation, migration, and differentiation.

Main Methods:

  • Review of existing literature on cell types within the adult CNS capable of generating oligodendrocytes.

Related Experiment Videos

  • Analysis of oligodendrocyte progenitors and multipotent cells in germinative areas.
  • Investigation of cellular responses to demyelination.

    • Main Results:

    • Several cell types, including post-mitotic oligodendrocytes, oligodendrocyte progenitors, and multipotent cells, can generate new oligodendrocytes after CNS demyelination.
    • Multipotent cells in germinative zones possess self-renewal and migration capabilities, representing a potential source for remyelination.
    • Understanding cell proliferation, migration, and differentiation is key to promoting endogenous repair.

    Conclusions:

    • Activating endogenous oligodendrocyte precursor cells offers a promising therapeutic strategy for MS and other demyelinating diseases.
    • This approach complements strategies targeting neuronal loss and inflammation.
    • Enhancing endogenous remyelination presents an alternative to cell transplantation therapies.