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Neurotransmitter dysfunction in patients with borderline personality disorder
I G Gurvits1, H W Koenigsberg, L J Siever
1Mount Sinai School of Medicine, New York, USA.
The Psychiatric Clinics of North America
|March 24, 2000
Summary
Neurotransmitter system dysfunction is linked to borderline personality disorder (BPD) traits like aggression and mood swings. Research highlights specific dysregulated neurotransmitter systems in BPD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Borderline personality disorder (BPD) is characterized by affective instability and impulsive aggression.
- Neurotransmitter systems play a crucial role in regulating mood and behavior.
Purpose of the Study:
- To review the evidence linking neurotransmitter system dysfunction to BPD traits.
- To identify specific neurotransmitter systems dysregulated in BPD.
Main Methods:
- Review of neurochemical assays.
- Analysis of receptor-density studies.
- Examination of neuroendocrine-challenge paradigms, functional neuroimaging, and candidate-gene research.
Main Results:
- Converging evidence points to dysregulation in specific neurotransmitter systems in BPD.
- Multiple lines of research support a neurobiological basis for BPD symptoms.
Conclusions:
- Neurotransmitter system dysfunction is a significant factor in the pathophysiology of borderline personality disorder.
- Further research into these systems may lead to targeted BPD treatments.