Long-term oral and craniofacial complications following pediatric bone marrow transplantation

Bone marrow transplantation (BMT) has become a common form of treatment for childhood diseases and disorders that directly or indirectly affect the production of stem cells which give origin to blood and immune system elements. The pre-transplant protocols include, but are not limited to, chemotherapy and/or radiotherapy, which can cause considerable acute and long-term undesired effects in the oral cavity and the craniofacial complex. This manuscript discusses the sequelae that a pediatric dentist may encounter when treating a BMT survivor.