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Thyroid function in healthy Thai neonates.

P Mahachoklertwattana1, A Sriphrapradang, S Supapannachart

  • 1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|March 24, 2000
PubMed
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This study establishes normal thyroid hormone levels for Thai newborns, providing crucial data for identifying congenital hypothyroidism. These findings aid in accurate screening and diagnosis in neonates.

Area of Science:

  • Neonatal endocrinology
  • Thyroid function testing
  • Pediatric diagnostics

Background:

  • Establishing normative data for thyroid hormones in neonates is essential for accurate diagnosis.
  • Thyroid dysfunction in newborns can lead to serious developmental issues if not detected early.
  • Previous data may not be representative of specific ethnic populations like Thai neonates.

Purpose of the Study:

  • To establish normative reference ranges for serum thyroxine (T4), free T4 (FT4), triiodothyronine (T3), and thyrotropin (TSH) in Thai neonates.
  • To provide data that can aid in the screening and diagnosis of congenital hypothyroidism in Thailand.
  • To understand the dynamic changes in neonatal thyroid hormone levels during the first month of life.

Main Methods:

  • A cross-sectional study involving 275 healthy, full-term Thai neonates.

Related Experiment Videos

  • Blood samples collected from umbilical cords and heel pads (infants aged 1-30 days).
  • Quantification of serum T4, FT4, T3, and TSH levels.

    • Main Results:

    • Serum T4 and FT4 levels peaked at 1-3 days postpartum, stabilizing within 2-4 weeks.
    • Serum T3 levels increased significantly from birth, reaching a steady state within one week.
    • Serum TSH levels decreased from birth, with minimal change after 3 days; the typical early surge was not observed due to sampling timing.

    Conclusions:

    • The study successfully generated normative data for neonatal thyroid function tests in Thai neonates.
    • These reference ranges are valuable for the detection and verification of congenital hypothyroidism in screening programs.
    • Recommendations are provided for optimal sample timing (umbilical cord or >48 hours old) for TSH screening to avoid false negatives.