Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New and future drugs in nerve-gut dysfunction.

L Bueno1

  • 1Dept. Pharmacology INRA, Toulouse, France. lbueno@toulouse.inra.fr

Italian Journal of Gastroenterology and Hepatology
|March 24, 2000
PubMed
Summary

Altered brain-gut communication contributes to functional bowel disorders. New research identifies targets for correcting these pathways, improving understanding and treatment of gastrointestinal issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of magnetic field fluctuations in TJ-II plasmas with new in-vessel helical arrays of magnetic coils.

The Review of scientific instruments·2022
Same author

Factors Associated With One-Year Mortality in Hospitalised Patients With Exacerbated Bronchiectasis.

Archivos de bronconeumologia·2022
Same author

Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.

British journal of pharmacology·2016
Same author

Protection of epithelial tight junction: a new therapeutic approach in the treatment of infectious diarrhea.

Acta gastro-enterologica Belgica·2014
Same author

Influence of a new 5-HT4 receptor partial agonist, YKP10811, on visceral hypersensitivity in rats triggered by stress and inflammation.

Neurogastroenterology and motility·2014
Same author

Pretransplant interferon-γ secretion by CMV-specific CD8+ T cells informs the risk of CMV replication after transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013

Area of Science:

  • Neurogastroenterology
  • Gastrointestinal Physiology
  • Neuroscience

Background:

  • Functional Bowel Disorders (FBDs) are increasingly linked to disrupted brain-gut interactions.
  • Understanding these complex communication pathways is crucial for FBDs.

Purpose of the Study:

  • To identify new therapeutic targets for correcting altered brain-gut communication.
  • To enhance the understanding of functional gastrointestinal disorders.

Main Methods:

  • Utilized experimental models of modified gut sensitivity.
  • Investigated emerging pharmacological tools.
  • Examined the role of neuropeptides and neurotransmitters.

Main Results:

  • Identified neuropeptides (tachykinins, bradykinin, CGRP) involved in neuronal sensitization.
  • Highlighted serotonin's role in gut hypersensitivity via various receptors.
  • Demonstrated the importance of central nervous system modulation.

Conclusions:

  • Altered brain-gut communication is a key factor in FBDs.
  • Local inflammation and central factors contribute to dysfunction.
  • Targeting neuropeptides, serotonin pathways, and brain modulation offers therapeutic potential.

Related Experiment Videos