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Atopic dermatitis and melanocytic naevi.

A Broberg¹, A Augustsson

¹Department of Dermatology, Lundby Hospital, Göteborg, Sweden. anders.broberg@psy.gu.se

The British Journal of Dermatology

|March 24, 2000

Summary

Adults with severe atopic dermatitis (AD) have significantly fewer common naevi (CN) than the general population. This study explored the link between AD, low CN counts, and elevated serum IgE levels.

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Area of Science:

Dermatology
Immunology
Genetics

Background:

Clinical observations suggest a potential link between severe atopic dermatitis (AD) and a reduced number of common naevi (CN).
Understanding this relationship may offer insights into AD pathogenesis and associated factors.

Purpose of the Study:

To investigate the hypothesis that adults with severe AD exhibit a lower prevalence of common naevi compared to a control group.
To explore potential correlations between serum immunoglobulin E (IgE) levels and the count of common naevi in patients with severe AD.

Main Methods:

A cohort of 51 Caucasian patients diagnosed with severe AD since childhood was assessed for the number of common naevi (CN) measuring 2 mm or larger.
A control group of 379 randomly selected subjects from a previous study was used for comparison.
Statistical analyses, including significance testing and correlation analysis, were employed to compare CN counts and investigate relationships with serum IgE.

Main Results:

Patients with severe AD demonstrated a significantly lower total body count of common naevi (mean 9) compared to the control group (mean 67) (P < 0.0001).
A significant negative correlation was observed between serum IgE levels and the number of common naevi in the AD group (r(s) = -0.50, P < 0.001).

Conclusions:

The study confirms a significantly lower number of common naevi in adults with severe atopic dermatitis.
The underlying mechanisms for this reduced naevi count remain unknown but may involve atopic inflammation, genetic factors, or eczema treatments.
Further research is warranted to elucidate the relationship between atopic dermatitis, immune factors like IgE, and melanocytic naevi development.

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