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Pityriasis lichenoides-like mycosis fungoides in children

J W Ko1, J Y Seong, K S Suh

  • 1Department of Dermatology, Kosin Medical Center, Pusan, South Korea.

The British Journal of Dermatology
|March 24, 2000
PubMed

Insights

Pityriasis lichenoides can mimic mycosis fungoides in children. Histopathology and T-cell receptor gene rearrangement confirmed mycosis fungoides in these cases, highlighting a rare presentation.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma.
  • Pityriasis lichenoides (PL) is a benign inflammatory condition often presenting with papular and maculary lesions.

Observation:

  • Three pediatric patients presented with clinical features suggestive of pityriasis lichenoides.
  • Histopathological examination revealed findings characteristic of mycosis fungoides, including disproportionate epidermotropism and Pautrier's microabscesses.

Findings:

  • Immunohistochemistry showed a predominance of T lymphocytes in lesional infiltrates.
  • T-cell receptor gamma chain gene rearrangement was detected in lesional skin biopsies from all three patients.
  • Human T-cell lymphotropic virus type 1 serology was negative in tested patients.

Implications:

  • This study identifies pityriasis lichenoides-like lesions as a potential, albeit unusual, presentation of mycosis fungoides in children.
  • Early recognition and appropriate diagnostic workup are crucial for managing pediatric MF presenting with atypical features.

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