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Related Experiment Videos

Onychomycosis: current treatment and future challenges.

D T Roberts1

  • 1Department of Dermatology, Southern General Hospital, Glasgow, UK. d.t.roberts@clinmed.gla.ac.uk

The British Journal of Dermatology
|March 24, 2000
PubMed
Summary

Onychomycosis, a common fungal nail infection, requires treatment due to disability and health impacts. Oral terbinafine offers high cure rates but challenges like treatment failure necessitate further research into combined therapies.

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Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Onychomycosis is a prevalent fungal nail infection, affecting 3-10% of Europeans, often caused by dermatophytes.
  • Many patients do not seek medical advice despite the infection's cosmetic and functional impact.
  • Untreated onychomycosis can lead to health issues, especially in the elderly, and poses a contamination risk.

Purpose of the Study:

  • To review the current understanding and treatment of onychomycosis.
  • To highlight the efficacy of oral antifungal agents, particularly terbinafine.
  • To identify persistent challenges and future research directions in onychomycosis management.

Main Methods:

  • Review of existing medical literature on onychomycosis prevalence, pathogens, and treatments.

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  • Analysis of comparative studies on oral antifungal agents like terbinafine and itraconazole.
  • Discussion of treatment failure rates and potential adjunctive therapies.

    • Main Results:

    • Oral terbinafine demonstrates superior efficacy (70-80% cure rate) and tolerability compared to other antifungals.
    • Terbinafine is identified as the most cost-effective treatment option.
    • A significant 20% treatment failure rate persists, indicating a need for improved strategies.

    Conclusions:

    • Medically confirmed onychomycosis warrants treatment due to its multifaceted negative impacts.
    • While oral terbinafine is highly effective, persistent failures necessitate further investigation.
    • Future research should explore individualized treatment durations, surgical interventions, and combined oral-topical therapies.