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Related Experiment Videos

Novel retinoids with receptor selectivity and functional selectivity.

A Johnson1, R A Chandraratna

  • 1Retinoid Research, Department of Biology, Allergan Inc., Irvine, California 92623-9534, USA.

The British Journal of Dermatology
|March 24, 2000
PubMed
Summary

Retinoids, like retinoic acid, regulate genes via receptors (RARs/RXRs). Selective retinoids offer improved efficacy and tolerability for treating conditions like psoriasis, cancer, and diabetes.

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Area of Science:

  • Molecular biology
  • Pharmacology
  • Dermatology

Background:

  • Retinoids influence cellular growth and differentiation by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs).
  • These receptors modulate gene expression, leading to widespread physiological effects due to receptor distribution and gene regulation capabilities.
  • Non-selective retinoids have broad therapeutic potential but are linked to significant adverse effects.

Purpose of the Study:

  • To explore the development of novel retinoids with improved efficacy and tolerability.
  • To highlight the strategy of designing receptor-selective and function-selective retinoids.
  • To discuss the potential applications of these advanced retinoids in various diseases.

Main Methods:

  • Investigating the mechanism of retinoid action through receptor binding and gene modulation.

Related Experiment Videos

  • Analyzing the structure-activity relationships of different retinoid compounds.
  • Evaluating the efficacy and tolerability of selective retinoids in preclinical and clinical settings.

    • Main Results:

    • Selective retinoids demonstrate targeted therapeutic effects with reduced side effects.
    • Tazarotene, a topical retinoid, exemplifies the success of this new generation for psoriasis treatment.
    • The development of selective retinoids is a promising strategy for novel therapeutic interventions.

    Conclusions:

    • Receptor-selective and function-selective retinoids represent a significant advancement in therapeutic design.
    • These novel retinoids offer a favorable balance of efficacy and tolerability.
    • Future applications are anticipated for dermatological diseases, cancer, and diabetes.