Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orbitofrontal cortex pathology in Alzheimer's disease.

G W Van Hoesen1, J Parvizi, C C Chu

  • 1Department of Anatomy and Cell Biology, University of Iowa and Division of Cognitive Neuroscience, Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. gary-van-hoesen@uiowa.edu

Cerebral Cortex (New York, N.Y. : 1991)
|March 24, 2000
PubMed
Summary

Alzheimer's disease (AD) extensively damages the orbitofrontal cortex with neurofibrillary tangles (NFTs), particularly in specific layers and regions. This widespread damage may explain non-memory behavioral changes in AD patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Consensus Meeting on Infection: Top 10 Evidence-Backed Recommendations and Insights.

The Journal of bone and joint surgery. American volume·2025
Same author

Optimal timing for reimplantation in the setting of two stage revision for prosthetic joint infection.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Optimal timing for reimplantation in the setting of two stage revision for prosthetic joint infection.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

[Translated article] International Consensus Meeting on Venous Thromboembolism (ICM-VTE) after orthopedic procedures, any change in our clinical practice?

Revista espanola de cirugia ortopedica y traumatologia·2022
Same author

International Consensus Meeting on Venous Thromboembolism (ICM-VTE) after orthopedic procedures, any change in our clinical practice?

Revista espanola de cirugia ortopedica y traumatologia·2022
Same author

Resuming Elective Orthopaedic Surgery During the COVID-19 Pandemic: Guidelines Developed by the International Consensus Group (ICM).

The Journal of bone and joint surgery. American volume·2020

Area of Science:

  • Neuroscience
  • Neuropathology
  • Geriatric Medicine

Background:

  • Alzheimer's disease (AD) is characterized by neurofibrillary tangle (NFT) pathology.
  • The orbitofrontal cortex (OFC) plays a crucial role in behavior and cognition.

Purpose of the Study:

  • To investigate the topography and laminar distribution of NFT pathology in the orbitofrontal cortex in Alzheimer's disease.
  • To correlate orbitofrontal cortex damage with behavioral changes in AD.

Main Methods:

  • Examination of neurofibrillary tangle (NFT) pathology in the orbitofrontal cortex.
  • Analysis of NFT laminar distribution and topographical extent in Alzheimer's disease cases.

Main Results:

  • NFT pathology is extensive in the orbitofrontal cortex in Alzheimer's disease.

Related Experiment Videos

  • NFTs are densest in layers III and V, particularly in dysgranular areas posterior to the transverse orbital sulcus.
  • Posterior and medial orbitofrontal areas (area 13, paraolfactory gyrus) and agranular fields near the olfactory tract show the most severe damage.

    • Conclusions:

    • Widespread orbitofrontal cortex damage in Alzheimer's disease affects projection neurons.
    • Orbitofrontal cortex pathology in AD likely contributes significantly to non-memory-related behavioral disturbances.