Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum testosterone levels decrease in middle age in women with the polycystic ovary syndrome.

S J Winters1, E Talbott, D S Guzick

  • 1University of Pittsburgh, Pittsburgh, Pennsylvania, USA. sjwint01@gwise.louisville.edu

Fertility and Sterility
|March 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?

Andrology·2018
Same author

The use of cell culture platforms to identify novel markers of bone and dentin resorption.

Orthodontics & craniofacial research·2017
Same author

Exosomes: novel regulators of bone remodelling and potential therapeutic agents for orthodontics.

Orthodontics & craniofacial research·2017
Same author

Environmental influences cause menstrual synchrony, not pheromones.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Characterization of Regulatory Extracellular Vesicles from Osteoclasts.

Journal of dental research·2016
Same author

Prognostic profiles and the effectiveness of assisted conception: secondary analyses of individual patient data.

Human reproduction update·2013

Testosterone levels in women with polycystic ovary syndrome (PCOS) decrease significantly after age 42, suggesting partial resolution of hyperandrogenism before menopause. However, elevated levels persist in older women, potentially increasing cardiovascular and cancer risks.

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Women's Health

Background:

  • Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism.
  • Longitudinal changes in testosterone levels with aging in women with PCOS are not well-established.

Purpose of the Study:

  • To investigate the relationship between aging and testosterone levels in women with PCOS.
  • To compare testosterone levels in women with PCOS to age-matched controls across different age groups.

Main Methods:

  • A follow-up cross-sectional study of 84 women with PCOS and 37 controls, recruited between 1970-1990.
  • Clinical data collected via questionnaire; fasting blood samples analyzed for total and non-SHBG-bound testosterone.
  • Participants ranged from 20-57 years of age.

Related Experiment Videos

Main Results:

  • Testosterone levels were similar in women with PCOS aged 20-42, then decreased by ~50% in those aged 42-47, stabilizing thereafter.
  • Younger and older women with PCOS had higher testosterone than controls, but levels were similar in the 42-47 age group.

Conclusions:

  • Hyperandrogenism in PCOS appears to partially resolve before menopause, potentially explaining improved cycle regularity with age.
  • Elevated testosterone levels in older women with PCOS may contribute to increased risks for cardiovascular disease and endometrial cancer.