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Related Experiment Videos

Enterococcal-type glycopeptide resistance genes in non-enterococcal organisms.

R Patel1

  • 1Division of Infectious Diseases and Infectious Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN, USA. patel.robin@mayo.edu

FEMS Microbiology Letters
|March 25, 2000
PubMed
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The origins of vancomycin resistance genes in enterococci remain unclear, despite their increasing use in medicine and agriculture. Environmental organisms show homologous gene clusters, but the exact source is still a mystery.

Area of Science:

  • Microbiology
  • Genetics
  • Molecular Biology

Background:

  • Vancomycin resistance in enterococci (VRE) is a growing clinical concern.
  • The widespread use of vancomycin and glycopeptides contributes to VRE emergence.
  • The precise origin of vancomycin resistance genes in enterococci is not well understood.

Purpose of the Study:

  • To investigate the potential sources of vancomycin resistance genes found in enterococci.
  • To explore the relationship between known resistance genes and environmental microorganisms.

Main Methods:

  • Comparative analysis of vancomycin resistance gene clusters.
  • Identification of homologous gene sequences in environmental bacteria.

Main Results:

Related Experiment Videos

  • Vancomycin resistance genes in certain Lactobacillus, Leuconostoc, Pediococcus, and Erysipelothrix species are not the source of high-level resistance in enterococci.
  • Gene clusters homologous to enterococcal vanA, vanB, and vanC have been identified in environmental organisms, including Paenibacillus popilliae, Amycolatopsis orientalis, and Streptomyces toyocaensis.

Conclusions:

  • The exact environmental source of enterococcal vancomycin resistance genes remains undetermined.
  • While environmental organisms harbor homologous gene clusters, they are not definitively identified as the primary source.
  • Further research is needed to elucidate the complete evolutionary pathway of vancomycin resistance in enterococci.