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[Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2)]
1Laboratoire de virologie des hospices civils de Lyon.
La Revue Du Praticien
|March 25, 2000
Summary
Herpes simplex virus (HSV) infections are common globally and can cause serious illness, especially in newborns or the central nervous system. While PCR offers sensitive diagnosis and acyclovir is an effective treatment, no preventative vaccine is currently available.
Area of Science:
- Virology
- Infectious Diseases
- Immunology
Context:
- Herpes simplex virus (HSV) infections are a widespread global health concern.
- HSV establishes latent infections, with potential for reactivation and diverse clinical manifestations.
- Infections can range from asymptomatic to life-threatening, particularly in neonates or cases involving the central nervous system.
Purpose:
- To review the epidemiology, clinical presentations, diagnostic methods, treatment, and prophylaxis of HSV infections.
- To highlight the importance of accurate HSV diagnosis using techniques like PCR.
- To discuss the current status of antiviral treatments and vaccine development for HSV.
Summary:
- HSV infections are highly prevalent worldwide, characterized by latency and reactivation.
- Diagnosis relies on sensitive methods like PCR, with type-specific serologies aiding prevalence studies.
- Acyclovir is a key treatment, though resistance is noted, primarily in immunocompromised individuals.
Impact:
- Accurate diagnosis and effective treatment are crucial for managing HSV infections, reducing morbidity and mortality.
- Understanding HSV epidemiology and pathogenesis informs public health strategies.
- The lack of an available vaccine underscores the need for continued research in HSV prevention.