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[Cytomegalovirus (CMV)]
1Service de bactériologie-virologie Hôpital Lariboisière, Paris.
Abstract:
Human cytomegalovirus (CMV) is an ubiquitous agent. CMV infection is a common, usually subclinical world wide infection with a tendency for virulence in congenitally-infected infants and immunosuppressed patients including allograft recipients and patients with AIDS. Anti-CMV drugs are used for the treatment of severe infections in immunosuppressed patients. Developments of vaccine to protect pregnant women from primary infection are in progress.
Insights
Human cytomegalovirus (CMV) causes widespread infections, often mild but severe in infants and immunocompromised individuals. Research is advancing anti-CMV drugs and vaccines for prevention and treatment.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Context:
- Human cytomegalovirus (CMV) is a ubiquitous virus with significant global prevalence.
- Infections are typically subclinical but can cause severe disease in specific populations.
Purpose:
- To outline the clinical significance of CMV infections.
- To discuss current therapeutic strategies and ongoing vaccine development.
Summary:
- CMV poses a risk to congenitally infected infants, allograft recipients, and individuals with AIDS.
- Antiviral medications are crucial for managing severe CMV infections in immunosuppressed patients.
Impact:
- Highlights the need for effective interventions against CMV.
- Emphasizes the potential of vaccines to prevent primary infections, particularly in pregnant women.