Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-altitude global amnesia.

J A Litch1, R A Bishop

  • 1Kunde Hospital, Solukhumbu District, Nepal. JLitch@yahoo.com

Wilderness & Environmental Medicine
|March 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Approach to the patient with polyneuropathy.

Lippincott's primary care practice·2002
Same author

Patient with memory loss.

Lippincott's primary care practice·2002
Same author

Polyneuropathy.

Lippincott's primary care practice·2002
Same author

Children at high altitude: an international consensus statement by an ad hoc committee of the International Society for Mountain Medicine, March 12, 2001.

High altitude medicine & biology·2001
Same author

Ketamine anesthesia at high altitude.

High altitude medicine & biology·2001
Same author

Reascent following resolution of high altitude pulmonary edema (HAPE).

High altitude medicine & biology·2001
Same journal

Time Required for Intranasal and Intravenous Analgesia Administration by Military Nurses in Simulated Trauma Care Scenarios: A Crossover Randomized, Controlled Trial.

Wilderness & environmental medicine·2026
Same journal

Tick-Borne Disease Prevention in Long-Distance Appalachian Trail Hikers: A Health Belief Model Approach.

Wilderness & environmental medicine·2026
Same journal

Icy Hot: A Case of Unexpected Heat Illness.

Wilderness & environmental medicine·2026
Same journal

Thermoregulatory Strain and Sleep Responses Across 14 Stages of the Dakar Rally.

Wilderness & environmental medicine·2026
Same journal

Systemic Symptoms Following a Wolf Spider Bite in a Child.

Wilderness & environmental medicine·2026
Same journal

Wilderness Medical Society Clinical Practice Guidelines for the Treatment of Pit Viper Envenomations in the United States and Canada: 2026 Update.

Wilderness & environmental medicine·2026
See all related articles

Transient global amnesia can occur at high altitudes, a condition termed high-altitude global amnesia (HAGA). This neurological event may result from hypocapnic cerebral vasoconstriction due to hypoxia.

Area of Science:

  • Neurology
  • Altitude Medicine
  • Physiology

Background:

  • Transient neurological symptoms at high altitude are documented, often without acute mountain sickness.
  • The specific phenomenon of transient global amnesia at high altitude requires further investigation.

Observation:

  • A case series identified patients experiencing transient global amnesia while at high altitude.
  • These episodes occurred without concurrent acute mountain sickness or other illnesses.

Findings:

  • The condition is termed high-altitude global amnesia (HAGA).
  • Pathophysiology suggests a link between hyperventilation, hypocapnic cerebral vasoconstriction, and localized brain hypoxia or ischemia.
  • Individual variability in hypoxic ventilatory response and cerebral vasomotor reactivity are key factors.

Related Experiment Videos

Implications:

  • Understanding HAGA is crucial for diagnosing and managing neurological events in high-altitude environments.
  • This research highlights the potential impact of altered blood gas levels on cerebral function at altitude.
  • Further studies are needed to confirm the proposed pathophysiology and explore preventative strategies.