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H19 and IGF-2 allele-specific expression in hepatoblastoma
J A Ross1, G A Radloff, S M Davies
1Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, USA.
British Journal of Cancer
|March 25, 2000
Abstract:
Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages.