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Updated: Aug 9, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Type 1 diabetes mellitus caused by treatment with interferon-beta
S Kado1, J Miyamoto, N Komatsu
1Department of Internal Medicine 5, Tokyo Medical University, Ami, Ibaragi.
Interferon-beta therapy can induce type 1 diabetes mellitus in adults. This case highlights the potential for autoimmune responses to IFN-beta, leading to hyperglycemia and insulin depletion.
Area of Science:
- Immunology
- Endocrinology
- Pharmacology
Background:
- Interferon-beta (IFN-beta) is a therapeutic agent used for various conditions.
- The potential for IFN-beta to induce autoimmune disorders is a recognized concern.
Observation:
- A 57-year-old male patient developed hyperglycemia during IFN-beta treatment.
- The patient required intensive insulin therapy and dietary management.
- GAD antibody positivity emerged during IFN-beta therapy and later resolved.
Findings:
- The patient was diagnosed with type 1 diabetes mellitus.
- Genetic predisposition (HLA-DR4, B54, DRB1*0405) was noted.
- Insulin secretion was found to be depleted.
Implications:
- IFN-beta therapy may trigger autoimmune type 1 diabetes in susceptible individuals.
- Monitoring for hyperglycemia and autoimmune markers is crucial in patients on IFN-beta.
- This case underscores the importance of considering drug-induced autoimmunity in clinical practice.
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