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Related Experiment Videos

Insulin-Like growth factor I: implications in aging.

E Arvat1, F Broglio, E Ghigo

  • 1Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy.

Drugs & Aging
|March 25, 2000
PubMed
Summary
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Growth hormone (GH) influences insulin-like growth factor-I (IGF-I) levels, which decline with age. This age-related decrease in IGF-I impacts various bodily systems, but exogenous IGF-I

Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Research

Background:

  • Circulating insulin-like growth factor-I (IGF-I) levels are primarily regulated by growth hormone (GH)-dependent hepatic synthesis.
  • Local IGF-I expression in peripheral tissues is generally GH-independent and influenced by tissue-specific hormones.
  • IGF-I levels exhibit significant age-related changes, increasing during puberty and decreasing in elderly individuals.

Purpose of the Study:

  • To explore the factors contributing to age-related decline in IGF-I levels.
  • To understand the impact of reduced IGF-I activity on age-associated physiological changes.
  • To investigate the potential of exogenous IGF-I therapy in mitigating age-related functional decline.

Main Methods:

  • Review of the somatomedin model and GH/IGF-I axis regulation.

Related Experiment Videos

  • Analysis of factors influencing circulating IGF-I, including somatotroph secretion, sex steroids, nutrition, and IGF-binding proteins.
  • Examination of the role of IGF-I in age-related changes across multiple organ systems.

    • Main Results:

    • Low IGF-I in the elderly is linked to impaired somatotroph secretion.
    • Declining gonadal sex steroids, malnutrition, and altered IGF-binding proteins also contribute to reduced IGF-I activity.
    • Age-related decreases in IGF-I partially explain functional changes in bones, muscles, cardiovascular, central nervous, and immune systems.

    Conclusions:

    • The age-related decline in IGF-I is multifactorial, involving hormonal, nutritional, and binding protein changes.
    • Reduced IGF-I activity is implicated in various age-associated physiological deteriorations.
    • The efficacy of exogenous IGF-I treatment in reversing age-related changes remains an open question requiring further investigation.