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Related Experiment Videos

Renal itch.

M Murphy1, A J Carmichael

  • 1Department of Dermatology, South Cleveland Hospital, Middlesbrough, UK.

Clinical and Experimental Dermatology
|March 25, 2000
PubMed
Summary
This summary is machine-generated.

Renal itch, a common symptom in chronic kidney disease patients, is not fully understood and often doesn't improve with dialysis. Effective treatments are limited, with renal transplantation offering the only definitive cure.

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Area of Science:

  • Nephrology
  • Dermatology
  • Clinical Medicine

Background:

  • Renal itch (pruritus) is a common and distressing symptom in patients with chronic renal failure.
  • It affects patients without primary skin disease or other identifiable causes of itching.
  • Its prevalence is increasing with the growing population of individuals with chronic kidney disease.

Purpose of the Study:

  • To review the current understanding of renal itch, including its characteristics, potential causes, and treatment options.
  • To highlight the challenges in managing this condition and the need for effective interventions.

Main Methods:

  • Literature review of studies on renal itch in patients with chronic renal failure.
  • Analysis of factors influencing pruritus, such as renal function and dialysis.

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  • Evaluation of reported treatment efficacies.

    • Main Results:

    • Renal itch prevalence increases with declining renal function but is not significantly improved by dialysis.
    • The exact cause of renal itch remains unclear, with histamine playing a minor role.
    • Potential contributing factors include hyperparathyroidism, abnormal cutaneous innervation, and endogenous opioids.

    Conclusions:

    • Treatment for renal itch is challenging, with limited options showing variable success.
    • Naltrexone, activated charcoal, UVB phototherapy, ondansetron, and topical capsaicin have demonstrated effectiveness in some cases.
    • Renal transplantation is considered the definitive treatment for renal itch.