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Role of CD8+ T cells in endogenous interleukin-10 secretion associated with visceral leishmaniasis

B J Holaday1

  • 1Núcleo de Medicina Tropical, Universidade Federal do Ceará, Fortaleza, CE, 60430-160, Brasil.

Memorias Do Instituto Oswaldo Cruz
|March 25, 2000
PubMed

This study examined the role and source of endogenous interleukin-10 (IL) secretion in visceral leishmaniasis (VL). The amounts of endogenous and Leishmania specific IL-10 and interferon-gamma (IFN) secreted by peripheral blood mononuclear cells (PBMC) from VL patients were compared. The correlation coefficient between endogenous IL-10 secretion and Leishmania specific IFN-gamma was -0. 77, suggesting a major role for endogenous IL-10 secretion in VL. The effects of CD4+ and CD8+ T cell clones, isolated from a treated VL patient, on IL-10 secretion were assayed by mixing the clones with autologous, inactivated PBMC. The CD8+ clones mediated increased levels of IL-10 secretion in the presence of PBMC alone suggesting that CD8+ T cells may mediate endogenous IL-10 secretion.

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