Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does left ventricular function improve with L-carnitine after acute myocardial infarction?

R Iyer1, A Gupta, A Khan

  • 1Department of Cardiology, Seth G.S. Medical College and K.E.M. Hospital, Parel, Mumbai, India.

Journal of Postgraduate Medicine
|March 29, 2000
PubMed
Summary

L-carnitine supplementation did not improve left ventricular function in patients with acute myocardial infarction. This study found L-carnitine to be a safe intervention but without significant clinical benefits for cardiac recovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzymatic antioxidants in erythrocytes following heavy metal exposure: possible role in early diagnosis of poisoning.

Bulletin of environmental contamination and toxicology·1997
Same author

The effects of midazolam and flumazenil on psychomotor function.

Journal of clinical anesthesia·1997
Same author

Adverse drug reactions from birth to early childhood.

Pediatric clinics of North America·1997
Same author

Value of radiography in diagnosing complications of cardioverter defibrillators implanted without thoracotomy in 437 patients.

AJR. American journal of roentgenology·1997
Same author

Secondary distal renal tubular acidosis in association with urological abnormalities.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·1997
Same author

Role of preoperative donor-specific transfusion and cyclosporine in haplo-identical living related renal transplant recipients.

Nephron·1997

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Acute anterior wall myocardial infarction (MI) significantly impacts left ventricular function.
  • L-carnitine is investigated for its potential cardioprotective effects.
  • Assessing L-carnitine's efficacy in preserving left ventricular function post-MI is crucial.

Purpose of the Study:

  • To evaluate the efficacy and safety of L-carnitine in patients with acute anterior wall MI.
  • To determine the effect of L-carnitine on left ventricular function, including ejection fraction and volumes.
  • To compare L-carnitine's impact against a placebo in a randomized controlled trial.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial involving 60 patients with acute anterior wall MI.

Related Experiment Videos

  • Patients received either intravenous L-carnitine or placebo for seven days, followed by oral administration for three months.
  • Echocardiography assessed regional wall motion, end-systolic volume (ESV), end-diastolic volume (EDV), and ejection fraction (EF) at multiple time points.

    • Main Results:

    • No statistically significant differences were observed in EF, ESV, or EDV between the L-carnitine and placebo groups at any assessment point.
    • The duration of chest pain before treatment initiation was comparable between groups.
    • No significant adverse effects were reported for L-carnitine, and mortality rates were similar between groups (p>0.05).

    Conclusions:

    • L-carnitine is a safe drug for patients with myocardial infarction.
    • L-carnitine supplementation does not demonstrate a significant effect on improving left ventricular function post-MI.
    • Further research may be needed to explore L-carnitine's role in different cardiac conditions or patient subgroups.